题名：Me₂(CH₂=CH)SiCN: a bifunctional ethylene equivalent for Diels-Alder reaction based controllable tandem synthesis

来源：Chemical Science

发表年代：2022

作者：Wen-Biao Wu, Bo-Shuai Mu, Jin-Sheng Yu*, Jian Zhou

Abstract：A bifunctional silyl reagent Me₂(CH₂=CH)SiCN has been developed as a novel ethylene equivalent for the Diels-Alder (DA) reaction. The use of this reagent enables the controllable synthesis of value-added cyclohexenyl ketones or 2-acyl cyclohexancarbonitrile derivatives through a five- or six-step tandem sequence based on a Wittig/cyanosilylation/DA reaction/retro-cyanosilylation/isomerization sequence that involves a temporary silicon-tethered intramolecular DA reaction.